MovDisordV3, Main, Exploration, bibRecord, 001B69

Multiple system atrophy is associated with changes in peripheral insulin‐like growth factor system

Identifieur interne : 001B69 ( Main/Exploration ); précédent : 001B68; suivant : 001B70

Multiple system atrophy is associated with changes in peripheral insulin‐like growth factor system

Auteurs : Maria Teresa Pellecchia [Italie] ; Rosario Pivonello [Italie] ; Katia Longo [Italie] ; Michela Manfredi [Italie] ; Alessandro Tessitore [Italie] ; Marianna Amboni [Italie] ; Claudia Pivonello [Italie] ; Mariangela Rocco [Italie] ; Autilia Cozzolino [Italie] ; Annamaria Colao [Italie] ; Paolo Barone [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-11-15.

RBID : ISTEX:9ED7A201D394460BFF602344192903ED8D9B5992

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Facteur croissance IGF, Insuline, Pathologie du système nerveux.

English descriptors

KwdEn :
- Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Insulin, Insulin (blood), Insulin like growth factor, Insulin-Like Growth Factor Binding Protein 1 (blood), Insulin-Like Growth Factor Binding Protein 3 (blood), Male, Middle Aged, Multiple System Atrophy (blood), Multiple system atrophy, Nervous system diseases, Sex Factors, Somatomedins (metabolism), Statistics, Nonparametric, insulin, insulin‐like growth factors, multiple system atrophy.
MESH :
- chemical , blood : Insulin, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3.
- blood : Multiple System Atrophy.
- chemical , metabolism : Somatomedins.
- Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Sex Factors, Statistics, Nonparametric.

Abstract

Insulin‐like growth factors (IGF‐I and IGF‐II) have been shown to have several neurotrophic actions and IGF system may be impaired in neurodegenerative disorders. The aim of this study was to investigate the IGF system in patients with MSA and to evaluate correlations between this endocrine system and clinical features of the disease. Serum levels of IGF‐I, IGF‐II, insulin, IGF‐binding protein 1 (BP1), and IGF‐binding protein 3 (BP3) were measured in 25 patients with probable MSA and 25 age, sex and BMI‐matched healthy controls. Clinical status of each patient was evaluated with the Unified Multiple System Atrophy Rating Scale (UMSARS) Part II and the Hoehn and Yahr rating scale. IGF‐I levels were significantly higher in MSA (164.1 + 66.2 μg/L) than in healthy controls (111.7 + 60.3 μg/L; p = 0.001). Insulin levels were significantly higher in MSA patients (21.9 ± 14.4 μU/mL) than in healthy controls (13.3 ± 5.1 μU/mL, p = 0.048). No significant difference was found in serum IGF‐II, IGF‐BP1, and IGF‐ BP3 levels between patients with MSA and healthy controls. There was a trend toward significantly higher IGF‐II levels in MSA patients with UMSARS score <26 (1026.3 ± 442.6 μg/L) than MSA patients with UMSARS score >26 (796.1 ± 234 μg/L, p = 0.055). The results of this study demonstrated that IGF system is altered in MSA. The degenerative process in MSA could lead to a compensatory increase in IGF‐I and insulin in an attempt to provide additional support to degenerating neurons. © 2010 Movement Disorder Society.

Url:

https://api.istex.fr/document/9ED7A201D394460BFF602344192903ED8D9B5992/fulltext/pdf

DOI: 10.1002/mds.23320

Affiliations:

Italie

Le document en format XML

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<author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name>
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<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
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<term>Insulin (blood)</term>
<term>Insulin like growth factor</term>
<term>Insulin-Like Growth Factor Binding Protein 1 (blood)</term>
<term>Insulin-Like Growth Factor Binding Protein 3 (blood)</term>
<term>Male</term>
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<term>Enzyme-Linked Immunosorbent Assay</term>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Sex Factors</term>
<term>Statistics, Nonparametric</term>
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<front><div type="abstract" xml:lang="en">Insulin‐like growth factors (IGF‐I and IGF‐II) have been shown to have several neurotrophic actions and IGF system may be impaired in neurodegenerative disorders. The aim of this study was to investigate the IGF system in patients with MSA and to evaluate correlations between this endocrine system and clinical features of the disease. Serum levels of IGF‐I, IGF‐II, insulin, IGF‐binding protein 1 (BP1), and IGF‐binding protein 3 (BP3) were measured in 25 patients with probable MSA and 25 age, sex and BMI‐matched healthy controls. Clinical status of each patient was evaluated with the Unified Multiple System Atrophy Rating Scale (UMSARS) Part II and the Hoehn and Yahr rating scale. IGF‐I levels were significantly higher in MSA (164.1 + 66.2 μg/L) than in healthy controls (111.7 + 60.3 μg/L; p = 0.001). Insulin levels were significantly higher in MSA patients (21.9 ± 14.4 μU/mL) than in healthy controls (13.3 ± 5.1 μU/mL, p = 0.048). No significant difference was found in serum IGF‐II, IGF‐BP1, and IGF‐ BP3 levels between patients with MSA and healthy controls. There was a trend toward significantly higher IGF‐II levels in MSA patients with UMSARS score <26 (1026.3 ± 442.6 μg/L) than MSA patients with UMSARS score >26 (796.1 ± 234 μg/L, p = 0.055). The results of this study demonstrated that IGF system is altered in MSA. The degenerative process in MSA could lead to a compensatory increase in IGF‐I and insulin in an attempt to provide additional support to degenerating neurons. © 2010 Movement Disorder Society.</div>
</front>
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<name sortKey="Manfredi, Michela" sort="Manfredi, Michela" uniqKey="Manfredi M" first="Michela" last="Manfredi">Michela Manfredi</name>
<name sortKey="Pivonello, Claudia" sort="Pivonello, Claudia" uniqKey="Pivonello C" first="Claudia" last="Pivonello">Claudia Pivonello</name>
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<name sortKey="Tessitore, Alessandro" sort="Tessitore, Alessandro" uniqKey="Tessitore A" first="Alessandro" last="Tessitore">Alessandro Tessitore</name>
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Movement Disorders (revue)

Multiple system atrophy is associated with changes in peripheral insulin‐like growth factor system

Multiple system atrophy is associated with changes in peripheral insulin‐like growth factor system

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.